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Tags
#nephrology
Question
What is the 7 step approach to drugs in nephro?
Answer
  1. What is the individual’s GFR? → no adjustment until <60ml/min (Cockcroft ‐Gault Equation)
  2. Is the drug effective in the setting of a reduced GFR? → e.g. thiazide doesn't work
  3. Is the drug safe in CKD? (metformin, bisphosphonates, meperidine)
  4. Is the drug itself nephrotoxic? (aminoglycosides, amphotericin B, NSAIDS)
  5. Is an immediate effect desired or needed? → loading dose will often be same but usually ↓ maintenance dose or ↑ interval to maintain the drug level at a safe therapeutic level
  6. Is the drug extensively eliminated by the kidney? (aminoglycosides, penicillins, cephalosporins, digoxin, vancomycin, lithium)
  7. Does the drug have an active / toxic metabolite that is renally eliminated? (meperidine)

Tags
#nephrology
Question
What is the 7 step approach to drugs in nephro?
Answer
?

Tags
#nephrology
Question
What is the 7 step approach to drugs in nephro?
Answer
  1. What is the individual’s GFR? → no adjustment until <60ml/min (Cockcroft ‐Gault Equation)
  2. Is the drug effective in the setting of a reduced GFR? → e.g. thiazide doesn't work
  3. Is the drug safe in CKD? (metformin, bisphosphonates, meperidine)
  4. Is the drug itself nephrotoxic? (aminoglycosides, amphotericin B, NSAIDS)
  5. Is an immediate effect desired or needed? → loading dose will often be same but usually ↓ maintenance dose or ↑ interval to maintain the drug level at a safe therapeutic level
  6. Is the drug extensively eliminated by the kidney? (aminoglycosides, penicillins, cephalosporins, digoxin, vancomycin, lithium)
  7. Does the drug have an active / toxic metabolite that is renally eliminated? (meperidine)

Summary

statusnot learnedmeasured difficulty37% [default]last interval [days]               
repetition number in this series0memorised on               scheduled repetition               
scheduled repetition interval               last repetition or drill

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