Answer
edema = Alterations in Starling (hydrostatic & oncotic) forces:
Increased hydrostatic pressure (Na+ retention)
• Heart failure
• Drugs: Eg. CCBs, NSAIDs, Thiazolidinediones, Minoxidil
Decreased oncotic pressure (hypoalbuminemia)
• Protein loss: nephrotic syndrome, protein losing enteropathy
• Reduced albumin synthesis: liver disease
Increased capillary permeability
• Diabetes
• Malnutrition
Approach: hx, p/e, labs, investigations