Pathogenesis of infectious endocarditis: Abnormal valves (focal disruption of valvular endothelium) lead to increased risk of endocarditis.
With endothelial disruption, thrombus is likely to develop. Then transient bacteremia allows bacteria to colonize the thrombus. More thrombus will develop and bacteria continue to grow, causing injury to underlying structures.
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sarahcho - (no access) - 04 CUNNINGHAM MMMD 2015-16 Pathology of Valve Disease (white).pdf, p35
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