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Pressure Hypertrophy 13 Left ventricular pressure overload induces genes that promote concentric hypertrophy Concentric hypertrophy increases contractile force while normalizing wall stress… … but ultimately results in a “musclebound” heart that does not fill normally (diastolic dysfunction) and is unable to increase stroke volume in response to demand Critical aortic stenosis = fixed cardiac output
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owner: sarahcho - (no access) - 05 HANSEN MMMD 2015-16 Valvular Heart Disease - Aortic Stenosis.pdf, p13


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