#medicine #surgery
shock consists of inadequate tissue perfusion marked by decreased delivery of required metabolic substrates and inad- equate removal of cellular waste products.This involves fail- ure of oxidative metabolism that can involve defects of oxygen (O 2 ) delivery, transport, and/or utilization. Current challenges include moving beyond fluid resuscitation based on endpoints of tissue oxygenation, and using therapeutic strategies at the cellular and molecular level.
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