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CVS - invasive diagnostic testing
#obgyn
Chorionic Villus Sampling (CVS):
• 10-14 wks
• Placental biopsy via transcervical or transabdominal approach
• Preliminary results for very high risk patients may be available in a few days [by fluorescence in-situ hybridization (“FISH”) analysis or QF-PCR (polymerase chain reaction)]; microarray may be done
• Early termination of affected pregnancies can be offered (psychological and physical advantages)
• Procedure related pregnancy loss rate 1-2%
• Slightly higher rate of cell culture failure than amniocentesis
• Rarely, inaccurate results due to placental mosaicism
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