Type II endometrial ca is usually characterized as non-estrogen related, and seem to have a different pathogenesis according to mutation analyses (p53 mutations common). Women with type II cancer are typically normal weight, multiparous and may be African American. Women with these tumours often present with advanced stage disease or more aggressive underlying histologic subtypes, which may not have abnormal vaginal bleeding early in their course. The prognosis for type II endometrial carcinoma is typically worse than type I with a poor five-year survival.