If you want to change selection, open original toplevel document below and click on "Move attachment"
Parent (intermediate) annotation
Open it V 1 receptors (V 1 Rs) are found in high density on vascular smooth muscle and cause vasoconstriction by an increase in intracellular calcium via the phosphatidyl–inositol-bisphosphonate cascade.</sp
Original toplevel document
Vasopressin receptor - Wikipedia f collecting duct, vascular endothelium and vascular smooth muscle cell insertion of AQP-2 water channels into apical membrane, induction of AQP-2 synthesis, releases von Willebrand factor and factor VIII, vasodilation
V 1 receptor[edit]
<span>V 1 receptors (V 1 Rs) are found in high density on vascular smooth muscle and cause vasoconstriction by an increase in intracellular calcium via the phosphatidyl–inositol-bisphosphonate cascade. [1] Cardiac myocytes also possess V 1 R. Additionally V 1 R are located in brain, testis, superior cervical ganglion, liver, blood vessels, and renal medulla. [1]
V 1 R is present on platelets, which upon stimulation induces an increase in intracellular calcium, facilitating thrombosis. Studies have indicated that due to polymorphism of platelet V 1 R there is significant heterogeneity in the aggregation response of normal human platelets to vasopressin. [1]
V 1 Rs are found in kidney, where they occur in high density on medullary interstitial cells, vasa recta, and epithelial cells of the collecting duct. [1] Vasopressin acts on medullary vasculature through V 1 R to reduce blood flow to inner medulla without affecting blood flow to outer medulla. V 1 Rs on the luminal membrane of the collecting duct limit the antidiuretic action of vasopressin. Additionally, vasopressin selectively contracts efferent arterioles probably through the V 1 R, but not the afferent arteriole. [1]
V 2 receptor[edit]
V 2 receptor (V 2 R) differs from V 1 R primarily in the number of sites susceptible to N-linked glycosylation; the V 1 R has sites at both the amino-terminus a
Summary
status
not learned
measured difficulty
37% [default]
last interval [days]
repetition number in this series
0
memorised on
scheduled repetition
scheduled repetition interval
last repetition or drill
Details
No repetitions
Discussion
Do you want to join discussion? Click here to log in or create user.