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Open it V 1 receptors (V 1 Rs) are found in high density on vascular smooth muscle and cause vasoconstriction by an increase in intracellular calcium via the phosphatidyl–inositol-bisphosphonate cascade.</sp
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Vasopressin receptor - Wikipedia f collecting duct, vascular endothelium and vascular smooth muscle cell insertion of AQP-2 water channels into apical membrane, induction of AQP-2 synthesis, releases von Willebrand factor and factor VIII, vasodilation
V 1 receptor
<span>V 1 receptors (V 1 Rs) are found in high density on vascular smooth muscle and cause vasoconstriction by an increase in intracellular calcium via the phosphatidyl–inositol-bisphosphonate cascade.  Cardiac myocytes also possess V 1 R. Additionally V 1 R are located in brain, testis, superior cervical ganglion, liver, blood vessels, and renal medulla. 
V 1 R is present on platelets, which upon stimulation induces an increase in intracellular calcium, facilitating thrombosis. Studies have indicated that due to polymorphism of platelet V 1 R there is significant heterogeneity in the aggregation response of normal human platelets to vasopressin. 
V 1 Rs are found in kidney, where they occur in high density on medullary interstitial cells, vasa recta, and epithelial cells of the collecting duct.  Vasopressin acts on medullary vasculature through V 1 R to reduce blood flow to inner medulla without affecting blood flow to outer medulla. V 1 Rs on the luminal membrane of the collecting duct limit the antidiuretic action of vasopressin. Additionally, vasopressin selectively contracts efferent arterioles probably through the V 1 R, but not the afferent arteriole. 
V 2 receptor
V 2 receptor (V 2 R) differs from V 1 R primarily in the number of sites susceptible to N-linked glycosylation; the V 1 R has sites at both the amino-terminus a
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