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Parent (intermediate) annotationOpen itG-Beta-gamma part of the G protein of M 2 can open K + channels, which slows down the heart rate
Original toplevel documentMuscarinic acetylcholine receptor M2 - Wikipediais claim instead found no significant association between the CHRM2 gene and intelligence. 
Mediating olfactory guided behaviors (e.g. odor discrimination, aggression, mating) 
Mechanism of action
<span>M 2 muscarinic receptors act via a G i type receptor, which causes a decrease in cAMP in the cell, generally leading to inhibitory-type effects. They appear to serve as autoreceptors. 
In addition, they modulate muscarinic potassium channels.   In the heart, this contributes to a decreased heart rate. They do so by the G beta gamma subunit of the G protein coupled to M 2 . This part of the G protein can open K + channels in the parasympathetic notches in the heart, which causes an outward current of potassium, which slows down the heart rate.
Few highly selective M 2 agonists are available at present, although there are several non-selective muscarinic agonists that stimulate M 2 , and a number of selectiv
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