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G-Beta-gamma part of the G protein of M 2 can open K + channels, which slows down the heart rate

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Muscarinic acetylcholine receptor M2 - Wikipedia
is claim instead found no significant association between the CHRM2 gene and intelligence. [8] Olfactory behavior[edit] Mediating olfactory guided behaviors (e.g. odor discrimination, aggression, mating) [9] Mechanism of action[edit] <span>M 2 muscarinic receptors act via a G i type receptor, which causes a decrease in cAMP in the cell, generally leading to inhibitory-type effects. They appear to serve as autoreceptors. [10] In addition, they modulate muscarinic potassium channels. [11] [12] In the heart, this contributes to a decreased heart rate. They do so by the G beta gamma subunit of the G protein coupled to M 2 . This part of the G protein can open K + channels in the parasympathetic notches in the heart, which causes an outward current of potassium, which slows down the heart rate. Ligands[edit] Few highly selective M 2 agonists are available at present, although there are several non-selective muscarinic agonists that stimulate M 2 , and a number of selectiv


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