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FAAH would, through the upregulation of AEA and 2-AG, elicit the effects of cannabinoid activation. Thus, FAAH inhibitors may serve as analgesic, anti-inflammatory, anxiolytic and antidepressant therapeutics.
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Molecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association : npj Systems Biology and Applications
rticular, it is believed that the overexpression of FAAH reduces the production of known endogenous cannabinoids, specifically, anandamide (AEA) and 2-arachidonoylglycerol (2-AG). 3 This makes FAAH an attractive drug target, as inhibition of <span>FAAH would, through the upregulation of AEA and 2-AG, elicit the effects of cannabinoid activation. Thus, FAAH inhibitors may serve as analgesic, anti-inflammatory, anxiolytic and antidepressant therapeutics. 4 However, the development of potent and safe FAAH inhibitors is hindered by their possible serious side effects. 5 In a recent clinical trial, the FAAH inhibitor BIA 10-2474, caused c


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