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First, we screen potential cellular off-targets of FAAH inhibitors on a structural proteome using BAs that represent the functional form of proteins in the cell.
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Molecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association : npj Systems Biology and Applications
t time, we develop a structural phenomics approach, which integrates heterogeneous data from structural genomics, chemical genomics and the biomedical literature, to reveal the cellular and physiological mechanism of drug–target interactions. <span>First, we screen potential cellular off-targets of FAAH inhibitors on a structural proteome using BAs that represent the functional form of proteins in the cell. Few computational methods that can screen a compound against the structural proteome-wide BAs, including uncharacterized binding sites, are available. To our knowledge, the method in th


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