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#biochem
Both monovalent (sodium and potas- sium) and divalent (particularly magnesium) ions have been found to interact with various sites on nucleic acids. Th ese interactions may be through direct metal-ion coordination or they may be mediated by water molecules
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under physiologically relevant conditions, these phosphates will be negatively charged and will tend to repel each other. As will be described further in Section 2.23, these negative charges can be shielded by metal ions. Both monovalent (sodium and potas- sium) and divalent (particularly magnesium) ions have been found to interact with various sites on nucleic acids. Th ese interactions may be through direct metal-ion coordination or they may be mediated by water molecules<html>

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