How many molecules of distamycin can bind side by side in a single region of the minor groove? How easy is this to accomodate?
Answer
Up to two molecules of distamycin can bind side by side in a single region of the minor groove; minor groove has to expand a lot, but change in groove width is fairly low energy
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#biochem
Question
How many molecules of distamycin can bind side by side in a single region of the minor groove? How easy is this to accomodate?
Answer
?
Tags
#biochem
Question
How many molecules of distamycin can bind side by side in a single region of the minor groove? How easy is this to accomodate?
Answer
Up to two molecules of distamycin can bind side by side in a single region of the minor groove; minor groove has to expand a lot, but change in groove width is fairly low energy
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Open it the antibiotic distamycin, which binds in the minor groove of DNA segments that have specifi c sequences (Figure 2.22B and C). Up to two molecules of distamycin can bind side by side in a single region of the minor groove, but the minor groove has to expand considerably in order to accommo- date two distamycin molecules. Since both types of complex can form at the same DNA sequence, with similar binding
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