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Non-hemolytic red cell breakdown causes increased bilirubin production and development of jaundice and occurs in a variety of conditions, including:
Extensive bruising from birth trauma Large cephalohematoma or other hemorrhage (e.g., intracranial) Polycythemia Swallowed blood (large amounts) during delivery.
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CLIPP 8 - neonatal jaundicedy-negative hemolysis occurs in infants who have red blood cell membrane defects (e.g., spherocytosis) or red blood cell enzyme defects (glucose-6- phosphate dehydrogenase or pyruvate kinase deficiency).
Other Causes
<span>Non-hemolytic red cell breakdown causes increased bilirubin production and development of jaundice and occurs in a variety of conditions, including:
Extensive bruising from birth trauma Large cephalohematoma or other hemorrhage (e.g., intracranial) Polycythemia Swallowed blood (large amounts) during delivery.
Metabolic errors
Crigler-Najjar syndrome: hyperbilirubinemia results from decreased bilirubin clearance caused by deficient or completely absent UDPGT. Galacto Summary
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Details