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Hemolysis leading to elevated circulating bilirubin and possible jaundice can be caused by a variety of disorders in the red blood cell, including:
Intrinsic cell membrane defects (such as spherocytosis and elliptocytosis) Enzyme disorders (such as G6PD deficiency and pyruvate kinase deficiency) Hemoglobinopathies (such as the thalassemias and sickle cell anemia)
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CLIPP 8 - neonatal jaundicenot suitable for young infants.
Hereditary Forms of Hemolysis
Because many causes of hemolysis are hereditary, a family history of anemia or jaundice can provide important information.
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<span>Hemolysis leading to elevated circulating bilirubin and possible jaundice can be caused by a variety of disorders in the red blood cell, including:
Intrinsic cell membrane defects (such as spherocytosis and elliptocytosis) Enzyme disorders (such as G6PD deficiency and pyruvate kinase deficiency) Hemoglobinopathies (such as the thalassemias and sickle cell anemia)
These disorders have varied modes of inheritance (X-linked, autosomal dominant, autosomal recessive) and may be found with greater prevalence among certain ethnicities, or Summary
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