Antibiotic class - Antibiotics - Spectrum of activity and comments
>>1st generation (usually GP but some GN coverage for simple inf's) - IV: cefazolin, PO: cephalexin - Gram +ve organisms (streptococci, staphylococci), Variable coverage against enteric gram negatives
that cause UTI (E. coli, K. pneumoniae)
>>2nd generation - IV: Cefuroxime, PO: Cefuroxime, Cefprozil - Gram +ve organisms (streptococci, staphylococci), H. influenzae, M. catarrhalis
>>3rd generation (covers streptococci well, which is why use for meningitis) - IV: Ceftriaxone, Cefotaxime, PO: Cefixime - Gram −ve organisms except P. aeruginosa. Streptococci including S. pneumoniae, group A
strep, group B strep (cefixime less so)
>>>>IV: Ceftazidime - Gram −ve organisms including P. aeruginosa, Poor gram positive coverage
**Enterococci are resistant to all current cephalosporins**