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Tags
#haematology #medicine
Question
What are the biochemical features of intravascular haemolysis ?
Answer
Increased Free plasma haemoglobin: released from RBCs
Methaemalbuminaemia: some free Hb is broken down in the circulation to produce haem and globin; haem combines with albumin to make methaemalbumin.
Decreased Plasma haptoglobin: mops up free plasma Hb, then removed by the liver.
Haemoglobinuria: causes red-brown urine, in absence of red blood cells.
Haemosiderinuria: occurs when haptoglobin-binding capacity is exceeded, causing free Hb to be filtered by the renal glomeruli, absorption of free Hb via the renal tubules and storage in the tubular cells as haemosiderin.

Tags
#haematology #medicine
Question
What are the biochemical features of intravascular haemolysis ?
Answer
?

Tags
#haematology #medicine
Question
What are the biochemical features of intravascular haemolysis ?
Answer
Increased Free plasma haemoglobin: released from RBCs
Methaemalbuminaemia: some free Hb is broken down in the circulation to produce haem and globin; haem combines with albumin to make methaemalbumin.
Decreased Plasma haptoglobin: mops up free plasma Hb, then removed by the liver.
Haemoglobinuria: causes red-brown urine, in absence of red blood cells.
Haemosiderinuria: occurs when haptoglobin-binding capacity is exceeded, causing free Hb to be filtered by the renal glomeruli, absorption of free Hb via the renal tubules and storage in the tubular cells as haemosiderin.
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