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Tuberous sclerosis complex (TSC) results from mutations in genes coding for proteins that have a tumor-suppressing effect. Disruption of these gene products allows abnormal cell proliferation in different tissues, including the skin, brain, lung, liver, and kidney. Mild TSC may be detected in adulthood. Renal angiomyolipomas are a characteristic kidney lesion in TSC and occur in 75% of patients on imaging.
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owner: ELBOMBARDO - (no access) - MKSAP_17.pdf, p3389


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