Infection-related glomerulonephritis such as endocarditis activates the alternative pathway of complement with low C3 and normal C4 levels. The classical pathway of complement is activated with cryoglobulinemic vasculitis (C4, and sometimes C3, is depressed) and systemic lupus erythematosus (both C3 and C4 are low).
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ELBOMBARDO - (no access) - MKSAP_17.pdf, p3532
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