Urine alkalinization increases the excretion of uric acid by increasing its solubility. However, in the setting of hyperphosphatemia, it can cause precipitation of calcium phosphate crystals in the kidney. Urine alkalinization is not necessary when rasburicase is used, and it role in TLS is controversial
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ELBOMBARDO - (no access) - MKSAP_17.pdf, p3564
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