Erythema nodosum is the most common cutaneous manifestation of inflammatory bowel disease, occurring in up to 20% of patients, particularly women. The lesions of EN are tender, subcutaneous nodules presenting as barely appreciable convexities on the skin surface, with a reddish hue in the acute phase. EN is frequently bilateral and symmetrical, and it usually occurs on the distal lower extremities, but it may also appear on the trunk, thighs, or upper extremities