The differential diagnosis of esophagitis in immunocompromised also includes possible viral causes. Cytomegalovirus often presents with a single ulcer in the esophagus. The diagnosis is established with biopsies from the ulcer base, and treatment should be with ganciclovir. Herpes simplex virus is also characterized by ulcers, typically multiple, found on upper endoscopy. The diagnosis is established with biopsy of the ulcer edge, and treatment should be with acyclovir.
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ELBOMBARDO - (no access) - MKSAP_17.pdf, p2663
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