Approximately 50% of these high-risk patients with acalculus cholecystitis will develop cholangitis, empyema, gangrene, or gallbladder perforation during their hospitalization. Supportive treatment with intravenous antibiotic coverage of anaerobic and gram-negative bacteria is required. Definitive therapy with cholecystectomy is preferred but may be contraindicated in severely ill patients
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- (no access) - MKSAP_17.pdf, p2707
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