With drug- receptor-response triad, when a drug combines with its receptor, a conformational change occurs in the receptor protein itself. No tissue response can occur without the structural shift. Evidence does suggest that events within the biosphere after drug associa- tion with the receptor are the principal regulatory variables of the response onset-offset time course
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Hadassah1 - (no access) - Nagelhout Nurse Anesthesia 5th Ed.pdf, p75
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