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Addition The combined effect of two drugs acting via the same mechanism is equal to that expected by simple addition of their individual actions. 1 + 1 = 2
Synergism The combined effect of two drugs is greater than the algebraic sum of their individual effects. 1 + 1 = 3
Potentiation The enhancement of the action of one drug by a second drug that has no detectable action of its own. 1 + 0 = 3
Antagonism The action of one drug opposes the action of another. 1 + 1 = 0
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