The anesthetist uses pharmacologic intervention to elicit a desired patient response. The site of the intervention is the bio- sphere, or the protein drug receptor, which is the primary regulator of the therapeutic response. Observed variation in patient drug response reflects the functionality of the biosphere and genetics, as well as physiologic variability
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Hadassah1 - (no access) - Nagelhout Nurse Anesthesia 5th Ed.pdf, p76
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