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Phosphorylated sugar molecules do not readily penetrate cell mem- branes, because there are no specific transmembrane carriers for these compounds, and because they are too polar to diffuse through the lipid core of membranes. The irreversible phosphorylation of glu- cose (Figure 8.12), therefore, effectively traps the sugar as cytosolic glucose 6-phosphate, thus committing it to further metabolism in the cell. Mammals have several isozymes of the enzyme hexokinase that catalyze the phosphorylation of glucose to glucose 6-phosphate
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owner: smelly_compost - (no access) - Lippincott's Biochemistry.pdf, p106


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