A decrease in levels of ACh is implicated in Alzheimer dementia and Huntington disease, whereas Parkinson disease is associated with a relative increase in ACh. Like histamine receptors, muscarinic receptors are subject to off-target blockade by antipsychotics and tricyclic antidepressants (TCAs), resulting in dry mouth, blurred vision, and urinary hesitancy.
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Frigg - (no access) - FirstAid Organ Systems.pdf, p507
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