There are two approaches for CMV prevention after SOT—universal prophylaxis and preemptive therapy. Universal prophylaxis consists of the administration of antivirals for varying duration, from as short as 3 months to as long as >12 months, for the prevention of CMV disease in patients at high risk ( 26). The main drawback with antiviral prophylaxis is the high inci- dence of late-onset CMV disease after discontinuation of prophylaxis and CMV D+/R- SOT recipients
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- (no access) - CMV ASM.pdf, p18
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