• Vancomycin: ▫ Narrow spectrum: mainly used for severe infections due to gram-positives resistant to other antibiotics ▫ Mode of action: binds to end of the pentapeptide chains (D-Ala-D-Ala) on NAM, blocking the transglycosylation & transpeptidation steps of peptidoglycan synthesis 18 1. Inhibitors of Cell Wall Synthesis ▫ Structural changes in the pentapeptide chain is one way that resistance can develop https://en.wikipedia.org/wiki/Vancomycin
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