The most important clinical questions are location of lesions (arms, head, legs, etc.), symptoms (pruritus, pain, etc.), dura- tion (acute or chronic), arrangement of lesions (solitary, gener- alized, annular, linear, etc.), morphology (macules, papules, plaques, vesicles, etc.), and color (red, blue, brown, black, white, yellow, etc.). The smart pathologist will not read out a skin biopsy of an inflammatory condition without calling for clinical information. Some pseudomalignancies are distin- guished from bona fide malignancies mainly by clinical dif- ferences (1.118). The difference between a lichenoid keratosis and lichen planus, which may be nearly identical histologi- cally, for example, primarily rests upon the former being a solitary papule and the latter being a rash with more than one lesion