Pathologists organize most of the histologic findings of skin lesions according to epidermal changes, dermal changes, adipose changes (panniculitis, if inflammatory), patterns or arrange- ments of inflammatory or neoplastic cells, and specific types of cells found. Architecture of skin lesions (arrangements of cells) is considered along with cytologic changes such as atypia. Cytologic atypia (hyperchromatism, pleomorphism, prominent nucleoli, increased nuclear to cytoplasmic ratio, and abnormal mitoses) is subjective, and the precise quanti- fication of atypia into mild, moderate or severe is in the eye of the beholder to some extent. Atypia is often used as evi- dence of malignancy, but it must be considered along with clinical findings and the lesion architecture. Dermatopatholo- gists with a background in clinical dermatology tend to emphasize the clinical information and cellular architecture over the cytologic features. Those with a pathology back- ground often stress cytology at the expense of clinical features and architecture. If the histologic findings do not fit the clini- cal situation, then the disparity must be rectified!