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Merkel cell carcinoma cells are usually positive for CK20 (perinuclear dot pattern) and neuron-specific enolase
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zen section). Sometimes Bowenoid changes (oil red-O negative carcinoma) in the epidermis coexist with sebaceous carcinoma in the dermis. EMA positivity is useful if frozen section not available <span>Merkel cell tumor (26.7): small cell tumor (1.130) is almost always present also in the dermis, in addition to the epidermotropic cells. Sometimes Bowen’s disease can coexist, or the small cells enter the epidermis. Merkel cell carcinoma cells are usually positive for CK20 (perinuclear dot pattern) and neuron-specific enolase Clear cell acanthoma (18.6): discrete clone of pale keratinocytes in a psoriasiform epidermis, positive for glycogen and keratin Hidroacanthoma simplex (23.10): this is an eccrine porom

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owner: gss4 - (no access) - book_Practical-Dermatopathology.pdf, p23


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