Bowen’s disease (squamous cell carcinoma in situ, 18.10): pale keratinocytes may be present which contain glycogen (PAS positive, diastase labile) with frequent dyskeratosis (1.27). Full-thickness atypia often involves basal cells also. High molecular weight keratin positive. Mucin stains, CEA, EMA, CK-7, CK-8 and low molecular weight keratin negative. However, cases have been published with exceptions, such as positive staining for CK-7 and EMA. Usually no pagetoid cells in the stratum corneum, which sometimes occurs with Paget’s disease and melanoma
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Open itpositive. Mucin in cytoplasm is often positive with mucicarmine, Alcian blue, colloidal iron, and PAS with and without diastase. Basal cells are often compressed and uninvolved. No dyskeratosis <span>Bowen’s disease (squamous cell carcinoma in situ, 18.10): pale keratinocytes may be present which contain glycogen (PAS positive, diastase labile) with frequent dyskeratosis (1.27). Full-thickness atypia often involves basal cells also. High molecular weight keratin positive. Mucin stains, CEA, EMA, CK-7, CK-8 and low molecular weight keratin negative. However, cases have been published with exceptions, such as positive staining for CK-7 and EMA. Usually no pagetoid cells in the stratum corneum, which sometimes occurs with Paget’s disease and melanoma Borst–Jadassohn phenomenon: discrete clones of basaloid, squamatized, or pale keratinocytes in the epidermis that appear different than their neighbors. This can be benign or malignant.Original toplevel document (pdf)
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gss4 - (no access) - book_Practical-Dermatopathology.pdf, p23
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