Borst–Jadassohn phenomenon: discrete clones of basaloid, squamatized, or pale keratinocytes in the epidermis that appear different than their neighbors. This can be benign or malignant. It is mainly seen with irritated seborrheic keratosis (18.2) or Bowen’s disease (18.10), and rarely with hidroacanthoma simplex (a form of eccrine poroma limited to the epidermis, 23.10).
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Open itcases have been published with exceptions, such as positive staining for CK-7 and EMA. Usually no pagetoid cells in the stratum corneum, which sometimes occurs with Paget’s disease and melanoma <span>Borst–Jadassohn phenomenon: discrete clones of basaloid, squamatized, or pale keratinocytes in the epidermis that appear different than their neighbors. This can be benign or malignant. It is mainly seen with irritated seborrheic keratosis (18.2) or Bowen’s disease (18.10), and rarely with hidroacanthoma simplex (a form of eccrine poroma limited to the epidermis, 23.10). Melanoma (20.11): S-100 (very sensitive, but not specific), HMB-45 and MART-1 (both very specific, but not sensitive) stains positive. Fontana melanin stain is also positive, but is lesOriginal toplevel document (pdf)
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gss4 - (no access) - book_Practical-Dermatopathology.pdf, p23
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