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Melanoma (20.11): S-100 (very sensitive, but not specific), HMB-45 and MART-1 (both very specific, but not sensitive) stains positive. Fontana melanin stain is also positive, but is less useful because keratinocytes may contain melanin transferred from melanocytes. Melanosomes by electron microscopy
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nant. It is mainly seen with irritated seborrheic keratosis (18.2) or Bowen’s disease (18.10), and rarely with hidroacanthoma simplex (a form of eccrine poroma limited to the epidermis, 23.10). <span>Melanoma (20.11): S-100 (very sensitive, but not specific), HMB-45 and MART-1 (both very specific, but not sensitive) stains positive. Fontana melanin stain is also positive, but is less useful because keratinocytes may contain melanin transferred from melanocytes. Melanosomes by electron microscopy Mycosis fungoides (24.1): malignant T-lymphocytes (sometimes cerebriform) in spaces called Pautrier microabscesses. Stains such as CD45 (leukocyte common antigen, used for screening), C

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owner: gss4 - (no access) - book_Practical-Dermatopathology.pdf, p23


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