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Normal cells growing in culture will not divide unless they are stimulated by one or more growth factors present in the culture medium.

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Oncogenes
expressed at abnormally-high levels contributes to converting a normal cell into a cancer cell. Cancer cells are cells that are engaged in uncontrolled mitosis . The signals for normal mitosis <span>Normal cells growing in culture will not divide unless they are stimulated by one or more growth factors present in the culture medium. Example: Epidermal Growth Factor (EGF). The growth factor binds to its receptor , an integral membrane protein embedded in the plasma membrane with its ligand -binding site exposed at t


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