Importantly, Prof. Boni and co-authors say that novel coronavirus itself has not arisen from recombination of any sarbecoviruses. The ability of the spike protein in the virus to bind to ACE2 human receptors had emerged within bats and is an ancestral trait shared with bat viruses and “not one acquired recently via recombination”. According to them, the results suggest the presence of a “single lineage” circulating in bats with properties that allowed it to infect human cells. This was also the case with the bat sarbecoviruses related to the 2002 SARS lineage.
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Unknown titleional Centre for Biological Sciences. “Many species of bat harbour several viruses which can cross over to new hosts. When we disrupt habitats, we will face more such threats.” No recombination <span>Importantly, Prof. Boni and co-authors say that novel coronavirus itself has not arisen from recombination of any sarbecoviruses. The ability of the spike protein in the virus to bind to ACE2 human receptors had emerged within bats and is an ancestral trait shared with bat viruses and “not one acquired recently via recombination”. According to them, the results suggest the presence of a “single lineage” circulating in bats with properties that allowed it to infect human cells. This was also the case with the bat sarbecoviruses related to the 2002 SARS lineage. The Nature Microbiology paper also challenges the notion that pangolins would have served as an intermediate host where the virus would have acquired its ability to infect human cells t Summary
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