Now, working on a different angle, the group has discovered that glucose controls the functions of a protein SIRT1 which in turn maintains everyday feed-fast cycles and is also associated with longevity. “In normal healthy individuals, SIRT1 protein levels are known to increase during fasting and decrease during feed, which is essential to maintain a balance between glucose and fat metabolism,” says Prof Kolthur-Seetharam.
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Unknown titlef Ullas Kolthur-Seetharam from the Department of Biological Sciences at TIFR, found the mechanism that triggers the liver to go from one stage to another in the feed-fast cycle. Role of glucose <span>Now, working on a different angle, the group has discovered that glucose controls the functions of a protein SIRT1 which in turn maintains everyday feed-fast cycles and is also associated with longevity. “In normal healthy individuals, SIRT1 protein levels are known to increase during fasting and decrease during feed, which is essential to maintain a balance between glucose and fat metabolism,” says Prof Kolthur-Seetharam. “Despite decades of work on the beneficial roles of SIRT1, metabolic factors that decrease its functions both during normal feed-fast cycles and in nutrient excess states (like obesity) Summary
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