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To estimate hazard ratios, we log-transformed variables with skewed distributions; these included albumin, creatinine, LDH, and SB2M.
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A comparison of landmark methods and time-dependent ROC methods to evaluate the time-varying performance of prognostic markers for survival outcomes | Diagnostic and Prognostic Research | Full Text
lactic hydrogenase (LDH), platelet count, and serum beta-2-microglobulin (SB2M). Barlogie et al. [4] used the same dataset to carry out the landmark analysis described above. Analytic approach <span>To estimate hazard ratios, we log-transformed variables with skewed distributions; these included albumin, creatinine, LDH, and SB2M. Additionally, recall that a hazard ratio represents the increase in risk associated with a one-unit increase in the marker value. Since the markers were measured on different scales, we


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