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Question
Sickle cell anaemia cause
Answer
adenine in the sixth codon of the beta-chain gene, GAG to GTG. This causes coding of valine instead of glutamate in position 6 of the Hb beta chain. T

Question
Sickle cell anaemia cause
Answer
?

Question
Sickle cell anaemia cause
Answer
adenine in the sixth codon of the beta-chain gene, GAG to GTG. This causes coding of valine instead of glutamate in position 6 of the Hb beta chain. T
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What is the role of hemoglobin S (HbS) in the pathogenesis of sickle cell disease (SCD)?
Maakaron, MD; Chief Editor: Emmanuel C Besa, MD more... References Share Email Print Feedback Close Facebook Twitter LinkedIn Google+ Answer HbS arises from a mutation substituting thymine for <span>adenine in the sixth codon of the beta-chain gene, GAG to GTG. This causes coding of valine instead of glutamate in position 6 of the Hb beta chain. The resulting Hb has the physical properties of forming polymers under deoxy conditions. It also exhibits changes in solubility and molecular stability. These properties are responsible f

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