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The predominant effect of mineralocorticoids is on the extracellu- lar balance of sodium and potassium in the distal tubule of the kidney. Aldosterone, produced solely in the zona glomerulosa, is the predominant mineralocorticoid in humans (about 50%); corti- costerone makes a small contribution to overall mineralocorticoid activity. Mineralocorticoids act on type 1 corticosteroid receptors, while glucocorticoids act on type 2 receptors, both having a very similar structure. The mineralocorticoid activity of cortisol is weak but cortisol is present in considerable excess. The mineralocorti- coid receptor in the kidney is protected from this excess by the intrarenal conversion (‘shuttle’) of cortisol to cortisone by 11βHSD type 2
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owner: nerdparty67 - (no access) - Adam Feather, David Randall, Mona Waterhouse - Kumar & Clark’s Clinical Medicine-Elsevier (2020).pdf, p620


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