It is theorized that reduced fiber content leads to decreased stool bulk and altered composition of the intestinal micro- biota. This change may increase synthesis of potentially toxic oxidative by-products of bacterial metabolism, which would be expected to remain in contact with the colonic mucosa for longer periods of time as a result of reduced stool bulk. High fat intake also enhances hepatic synthesis of cholesterol and bile acids, which can be converted into carcinogens by intestinal bacteria.
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- (no access) - [Robbins Pathology] Vinay Kumar, Abul Abbas, Jon Aster - Robbins & Cotran Pathologic Basis of Disease (2020, Elsevier) - libgen.lc.pdf, p804
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