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pathogenesis of colorectal carcinoma
#Pathology #abdomen #surgery

two genetic pathways have been described: the APC/β-catenin pathway, which is activated in the classic adenoma-carcinoma sequence,

and the MSI pathway, which is associated with defects

in DNA mismatch repair and accumulation of mutations

in microsatellite repeat regions of the genome

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owner: nerdparty67 - (no access) - [Robbins Pathology] Vinay Kumar, Abul Abbas, Jon Aster - Robbins & Cotran Pathologic Basis of Disease (2020, Elsevier) - libgen.lc.pdf, p804


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