Pain is a late symptom, but pain of a colicky character may accompany advanced tumours of the rectosigmoid, owing to a degree of obstruction. Advanced cancers invading outside the mesorectum may infiltrate the prostate or bladder ante- riorly or the sacral plexus posteriorly, giving rise to severe, intractable pain.
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- (no access) - McCaskie, A. W._ O'Connell, P. Ronan_ Williams, Norman S - Bailey & Love's Short practice of surgery (2018, CRC Press) - libgen.li.pdf, p1350
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