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Management of a locally advanced colorectal carcinoma
#Surgery #abdomen #carcinoma #colorectal
When a tumour appears to be locally advanced (i.e. invading a neighbouring structure or threatening to breach the circumferential resection margin), the use of neoadjuvant (preoperative) radiotherapy or chemoradiotherapy is usually considered. Long-course chemoradiotherapy is given as 5 fractions of radiotherapy combined with chemotherapy over a 6-week period. The aim is to down-stage the cancer and increase the chances of a complete resection with clear onco- logical margins. Alternatively, preoperative ‘short-course’ (5 days) radiotherapy can be used if the resection margins are not threatened but the cancer is still at high risk for local recurrence (e.g. peri-rectal lymph node involvement).
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owner: nerdparty67 - (no access) - McCaskie, A. W._ O'Connell, P. Ronan_ Williams, Norman S - Bailey & Love's Short practice of surgery (2018, CRC Press) -, p1353


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