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#harrison #medicine
PRL consists of 198 amino acids and has a molecular mass of 21,500 kDa; it is weakly homologous to GH and human placen- tal lactogen (hPL), reflecting the duplication and divergence of a com- mon GH-PRL-hPL precursor gene. PRL is synthesized in lactotropes, which constitute about 20% of anterior pituitary cells. Lactotropes and somatotropes are derived from a common precursor cell that may give rise to a tumor that secretes both PRL and GH. Marked lactotrope cell hyperplasia develops during pregnancy and the first few months of lactation. These transient functional changes in the lactotrope popula- tion are induced by estrogen
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  • owner: nerdparty67 - (no access) - HARRISON Principles of Internal Medicine 20th Edition.pdf, p2660
  • owner: Anonymouse - (no access) - @MBS_MedicalBooksStore_2018_Harrison's.pdf, p2706


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