Major risk factors for liver disease that should be sought in the clin- ical history include details of alcohol use, medication use (including herbal compounds, birth control pills, and over-the-counter medica- tions), personal habits, sexual activity, travel, exposure to jaundiced or other high-risk persons, injection drug use, recent surgery, remote or recent transfusion of blood or blood products, occupation, accidental exposure to blood or needlestick, and familial history of liver disease.