- ! Na + , ¯ K + , ! pH, ! bicarb, ! CO2. - Remember that all arrows go the same direction as aldosterone, except for potassium, which is the opposite. - Aldosterone upregulates the sodium-potassium ATPase pump on the basolateral membrane of the cortical collecting duct in the kidney. This causes Na + reabsorption and K + secretion. Water follows sodium; this will function to increase volume status and blood pressure. - Aldosterone also upregulates an apical H + -ATPase pump. If protons are kicked out into the urine, the patient develops metabolic alkalosis (i.e., bicarb goes up). - CO2 is acidic. If we have a metabolic alkalosis, we want to retain acidic CO2, so we slow respiratory rate – i.e., metabolic alkalosis with respiratory compensation.
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- ! Na + , ¯ K + , ! pH, ! bicarb, ! CO2. - Remember that all arrows go the same direction as aldosterone, except for potassium, which is the opposite. - Aldosterone upregulates the sodium-potassium ATPase pump on the basolateral membrane of the cortical collecting duct in the kidney. This causes Na + reabsorption and K + secretion. Water follows sodium; this will function to increase volume status and blood pressure. - Aldosterone also upregulates an apical H + -ATPase pump. If protons are kicked out into the urine, the patient develops metabolic alkalosis (i.e., bicarb goes up). - CO2 is acidic. If we have a metabolic alkalosis, we want to retain acidic CO2, so we slow respiratory rate – i.e., metabolic alkalosis with respiratory compensation.
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