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In other words, mutant tumor suppressor alleles are usually recessive, whereas mutant oncogene alleles are typically dominant.
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Tumor suppressor gene - Wikipedia
ein must be affected before an effect is manifested.[7] If only one allele for the gene is damaged, the other can still produce enough of the correct protein to retain the appropriate function. <span>In other words, mutant tumor suppressor alleles are usually recessive, whereas mutant oncogene alleles are typically dominant. Models of tumor suppression Illustration of two-hit hypothesis Proposed by A.G. Knudson for cases of retinoblastoma.[7] He observed that 40% of U.S cases were caused by a mutation in th


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